{"id":110277,"date":"2020-07-10T10:18:07","date_gmt":"2020-07-10T14:18:07","guid":{"rendered":"https:\/\/wp.oviahealth.com\/guide\/110277\/what-is-the-brca-gene\/"},"modified":"2022-12-01T00:15:17","modified_gmt":"2022-12-01T05:15:17","slug":"what-is-the-brca-gene","status":"publish","type":"article","link":"https:\/\/www.oviahealth.com\/guide\/110277\/what-is-the-brca-gene\/","title":{"rendered":"Learn about the BRCA gene and why it’s important"},"content":{"rendered":"

The BRCA gene is an abbreviation for the ‘BR<\/strong><\/span>east CA<\/strong><\/span>ncer’ gene. Both BRCA1 and BRCA2 are different genes that have been shown to relate to an individual\u2019s risk of developing breast cancer. <\/span><\/p>\n

Helpful information about the BRCA gene<\/h2>\n

All people carry these genes, and, typically, the genes actually work to help prevent breast cancer. They do this by operating as tumor suppression genes, as they work to help repair breaks in DNA that can cause cause cancer and tumor growth. <\/span><\/p>\n

However, a small percent of the population carries a mutated BRCA gene <\/span>\u2014 about 1 in 300 carry a BRCA1 mutation and about 1 in 800 carry a BRCA2 mutation <\/span>\u2014 which means that the gene might not be effective at working as a tumor suppression gene to help prevent breast cancer. This means that people with a mutation of the BRCA gene are more likely to develop breast cancer and other cancers and more likely to do so at a younger age. People with a BRCA mutation can also pass this mutation down to their children. <\/span><\/p>\n

The statistics about the BRCA gene<\/h3>\n

Approximately 1 in 8 American women <\/span>\u2014 or 12% <\/span>\u2014 will get breast cancer<\/a> in her lifetime, but women with certain genetic mutations have a higher risk. It\u2019s estimated that 55-65% of women with the BRCA1 mutation and 45% of women with the BCRA2 mutation will develop breast cancer by age 70. And women with one of these mutations are more likely to develop more aggressive and difficult to treat breast cancer and, if they\u2019re able to have their cancer successfully treated, to have a higher than average chance of developing a second cancer <\/span>\u2014 called recurrence.<\/span><\/p>\n

These numbers may sound scary, but the vast majority of breast cancer cases can be treated with early detection. This is even the case with people who have one of the BRCA mutations. And less than 10% of women diagnosed with breast cancer have such a mutation. <\/span><\/p>\n

Anyone can carry the BRCA1 and BRCA2 mutations, but people of certain ethic groups are more likely to carry the mutation, including individuals of Eastern or Central European Jewish, French Canadian, and Icelandic descent. <\/span><\/p>\n

People who likely have an increased risk of these sort of inherited mutations <\/span>\u2014 based on personal health, family history of cancer, or who have a specific type of breast cancer <\/span>\u2014 may wish to take a BRCA gene test. This blood test analyzes DNA to identify whether or not the individual carries an inherited BRCA mutation. If the test is positive, an individual can then work with a doctor to understand their cancer risk. If the test is negative, this means there is no mutation. However, sometimes the test may reveal gene variants that may or may not be associated with increased risk of breast and ovarian cancer. If it seems like a genetic test might be appropriate for you, you could work with a genetic counselor to decide what sort of genetic testing options would be best for you and discuss what the results will mean for your health.
\n<\/span><\/p>\n

\n
Sources<\/h5>\n
    \n
  • Mayo Clinic Staff. \u201cBRCA gene test for breast and ovarian cancer risk.\u201d Mayo Clinic. Mayo Foundation for Medical Education and Research, September 1 2016. Retrieved December 18 2017. https:\/\/www.mayoclinic.org\/tests-procedures\/brca-gene-test\/about\/pac-20384815.<\/span><\/li>\n
  • \u201cBRCA: The Breast Cancer Gene.\u201d National Breast Cancer Foundation, Inc. <\/span>National Breast Cancer Foundation, Inc. <\/span><\/em>Retrieved December 18 2017. http:\/\/www.nationalbreastcancer.org\/what-is-brca.<\/span><\/li>\n
  • \u201cBRCA1 and BRCA2: Cancer Risk and Genetic Testing.\u201d <\/span>National Cancer Institute at the National Institutes of Health. <\/span><\/em>U.S. Department of Health and Human Services, April 1, 2015. https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/genetics\/brca-fact-sheet#q2. <\/span><\/li>\n
  • \u201cPFS007: BRCA1 and BRCA2 Mutations.\u201d <\/span>The American Congress of Obstetricians and Gynecologists. <\/span><\/em>The American College of Obstetricians and Gynecologists, October 2017. Retrieved December 18 2017. https:\/\/www.acog.org\/Patients\/FAQs\/BRCA1-and-BRCA2-Mutations.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    The BRCA gene, also known as the ‘BReast CAncer’ gene, is a gene that’s carried by all people. But a small percentage of the population carries a mutation that can lead to breast cancer. Read on to learn more. <\/p>\n","protected":false},"author":1,"featured_media":229802,"template":"","format":"standard","meta":{"ovia_author_name":"","ovia_author_prefix":"","ovia_author_image":"","ovia_content_type_id":"176","ovia_product_mode":"2","ovia_days_from_signup":"104","ovia_days_from_lmp":"","ovia_days_from_baby_birth":"","ovia_days_from_enroll":"","ovia_health_module_days_from":"","ovia_article_for_email_days_from":"","ovia_health_module":"","ovia_legacy_id2":"","ovia_ttc":"","ovia_article_subtype":"","ovia_health_symptom":"","ovia_partner_id":"","ovia_partner_custom_group":"","ovia_legacy_category":"122","ovia_legacy_category2":"","ovia_content_url_id":"110277","ovia_include_share_buttons":"","ovia_fertility_goal":"3,1,2","ovia_secondary_module":"","ovia_trimester":"","ovia_child_age":"","ovia_share_image":"","ovia_more_menu_image":"","ovia_button1_url":"","ovia_days_from_postpartum":"","footnotes":"","_links_to":"","_links_to_target":""},"fert-category":[37,33,20,10,16,17],"preg-category":[],"parent-category":[],"fert-tag":[191,189,188],"preg-tag":[],"parent-tag":[],"class_list":["post-110277","article","type-article","status-publish","format-standard","has-post-thumbnail","hentry","fert-category-general-health","fert-category-health-and-wellness","fert-category-preconception-health","fert-category-reproductive-health","fert-category-reproductive-healthcare","fert-category-reproductive-issues-and-conditions","fert-tag-patient-self-advocacy","fert-tag-reproductive-health-care-providers","fert-tag-wellness-exams"],"yoast_head":"\nWhat is the brca gene? | Learn the specifics about it<\/title>\n<meta name=\"description\" content=\"Here\u2019s what you need to know about the BRCA gene. 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